Xanthine oxidase inhibitor - Revision history

Fire at 11:15, 22 April 2024

2024-04-22T11:15:37Z

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	A '''xanthine oxidase inhibitor''' is any substance that [[Enzyme inhibitor\|inhibits]] the activity of [[xanthine oxidase]], an [[enzyme]] involved in [[purine metabolism]]. In [[human]]s, inhibition of xanthine oxidase reduces the production of [[uric acid]], and several [[medication]]s that inhibit xanthine oxidase are [[Indication (medicine)\|indicated]] for treatment of [[hyperuricemia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]].		A '''xanthine oxidase inhibitor''' is any substance that [[Enzyme inhibitor\|inhibits]] the activity of [[xanthine oxidase]], an [[enzyme]] involved in [[purine metabolism]]. In [[human]]s, inhibition of xanthine oxidase reduces the production of [[uric acid]], and several [[medication]]s that inhibit xanthine oxidase are [[Indication (medicine)\|indicated]] for treatment of [[hyperuricemia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]].

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2024-04-22T10:48:29Z

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Fire at 10:47, 22 April 2024

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Fire at 10:47, 22 April 2024

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 {{Short description|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}}
 A '''xanthine oxidase inhibitor''' is any substance that [[Enzyme inhibitor|inhibits]] the activity of [[xanthine oxidase]], an [[enzyme]] involved in [[purine metabolism]].  In [[human]]s, inhibition of xanthine oxidase reduces the production of [[uric acid]], and several [[medication]]s that inhibit xanthine oxidase are [[Indication (medicine)|indicated]] for treatment of [[hyperuricemia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]].

Fire: Marked this version for translation

2024-04-22T10:22:42Z

Marked this version for translation

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	<languages />		<languages />
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			<!--T:1-->
	{{Short description\|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}}		{{Short description\|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}}
	A '''xanthine oxidase inhibitor''' is any substance that [[Enzyme inhibitor\|inhibits]] the activity of [[xanthine oxidase]], an [[enzyme]] involved in [[purine metabolism]]. In [[human]]s, inhibition of xanthine oxidase reduces the production of [[uric acid]], and several [[medication]]s that inhibit xanthine oxidase are [[Indication (medicine)\|indicated]] for treatment of [[hyperuricemia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]].		A '''xanthine oxidase inhibitor''' is any substance that [[Enzyme inhibitor\|inhibits]] the activity of [[xanthine oxidase]], an [[enzyme]] involved in [[purine metabolism]]. In [[human]]s, inhibition of xanthine oxidase reduces the production of [[uric acid]], and several [[medication]]s that inhibit xanthine oxidase are [[Indication (medicine)\|indicated]] for treatment of [[hyperuricemia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]].

			<!--T:2-->
	Xanthine oxidase inhibitors are of two kinds: [[purine analogue]]s and others. Purine analogues include [[allopurinol]], [[oxypurinol]], and [[tisopurine]]. Others include [[febuxostat]], [[topiroxostat]], and [[inositol]]s ([[phytic acid]] and [[Inositol\|myo-inositol]]).		Xanthine oxidase inhibitors are of two kinds: [[purine analogue]]s and others. Purine analogues include [[allopurinol]], [[oxypurinol]], and [[tisopurine]]. Others include [[febuxostat]], [[topiroxostat]], and [[inositol]]s ([[phytic acid]] and [[Inositol\|myo-inositol]]).

			<!--T:3-->
	In experiments, numerous [[natural product]]s have been found to inhibit xanthine oxidase [[in vitro]] or in model animals ([[mouse\|mice]], [[rat]]s). These include three [[flavonoid]]s that occur in many different fruits and vegetables: [[kaempferol]], [[myricetin]], and [[quercetin]]. More generally, planar flavones and flavonols with a 7-hydroxyl group inhibit xanthine oxidase. An [[essential oil]] extracted from ''[[Cinnamomum osmophloeum]]'' inhibits xanthine oxidase in [[mouse\|mice]]. The natural product [[propolis]] from selected sources inhibits xanthine oxidase in [[rat]]s; the specific substance responsible for this inhibition has not been identified, and the generality of these findings is unknown. An extract of leaves of ''[[Pistacia integerrima]]'' also inhibits xanthine oxidase at a level that appears to merit further research.		In experiments, numerous [[natural product]]s have been found to inhibit xanthine oxidase [[in vitro]] or in model animals ([[mouse\|mice]], [[rat]]s). These include three [[flavonoid]]s that occur in many different fruits and vegetables: [[kaempferol]], [[myricetin]], and [[quercetin]]. More generally, planar flavones and flavonols with a 7-hydroxyl group inhibit xanthine oxidase. An [[essential oil]] extracted from ''[[Cinnamomum osmophloeum]]'' inhibits xanthine oxidase in [[mouse\|mice]]. The natural product [[propolis]] from selected sources inhibits xanthine oxidase in [[rat]]s; the specific substance responsible for this inhibition has not been identified, and the generality of these findings is unknown. An extract of leaves of ''[[Pistacia integerrima]]'' also inhibits xanthine oxidase at a level that appears to merit further research.

			<!--T:4-->
	In [[folk medicine]] the [[tree fern]] ''[[Cyathea spinulosa]]'' (formerly ''Alsophila spinulosa'') has been used for gout, but its most active component, [[caffeic acid]], is only a weak inhibitor of xanthine oxidase.		In [[folk medicine]] the [[tree fern]] ''[[Cyathea spinulosa]]'' (formerly ''Alsophila spinulosa'') has been used for gout, but its most active component, [[caffeic acid]], is only a weak inhibitor of xanthine oxidase.

			<!--T:5-->
	{{Enzyme inhibition}}		{{Enzyme inhibition}}
	{{Antigout preparations}}		{{Antigout preparations}}
	{{Purinergics}}		{{Purinergics}}

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	{{二次利用\|date=10 December 2023}}		{{二次利用\|date=10 December 2023}}
	[[Category:Xanthine oxidase inhibitors\| ]]		[[Category:Xanthine oxidase inhibitors\| ]]
	[[Category:Uric acid]]		[[Category:Uric acid]]
	</translate>		</translate>

Fire: Created page with " {{Short description|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}} A '''xanthine oxidase inhibitor''' is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are Indica..."

2024-04-22T09:59:00Z

Created page with "<languages /> <translate> {{Short description|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}} A '''xanthine oxidase inhibitor''' is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are Indica..."

New page

<languages />
<translate>
{{Short description|Substance that decreases activity of xanthine oxidase, an enzyme involved in purine metabolism}}
A '''xanthine oxidase inhibitor''' is any substance that [[Enzyme inhibitor|inhibits]] the activity of [[xanthine oxidase]], an [[enzyme]] involved in [[purine metabolism]]. In [[human]]s, inhibition of xanthine oxidase reduces the production of [[uric acid]], and several [[medication]]s that inhibit xanthine oxidase are [[Indication (medicine)|indicated]] for treatment of [[hyperuricemia]] and related medical conditions including [[gout]]. Xanthine oxidase inhibitors are being investigated for management of [[reperfusion injury]].

Xanthine oxidase inhibitors are of two kinds: [[purine analogue]]s and others. Purine analogues include [[allopurinol]], [[oxypurinol]], and [[tisopurine]]. Others include [[febuxostat]], [[topiroxostat]], and [[inositol]]s ([[phytic acid]] and [[Inositol|myo-inositol]]).

In experiments, numerous [[natural product]]s have been found to inhibit xanthine oxidase [[in vitro]] or in model animals ([[mouse|mice]], [[rat]]s). These include three [[flavonoid]]s that occur in many different fruits and vegetables: [[kaempferol]], [[myricetin]], and [[quercetin]]. More generally, planar flavones and flavonols with a 7-hydroxyl group inhibit xanthine oxidase. An [[essential oil]] extracted from ''[[Cinnamomum osmophloeum]]'' inhibits xanthine oxidase in [[mouse|mice]]. The natural product [[propolis]] from selected sources inhibits xanthine oxidase in [[rat]]s; the specific substance responsible for this inhibition has not been identified, and the generality of these findings is unknown. An extract of leaves of ''[[Pistacia integerrima]]'' also inhibits xanthine oxidase at a level that appears to merit further research.

In [[folk medicine]] the [[tree fern]] ''[[Cyathea spinulosa]]'' (formerly ''Alsophila spinulosa'') has been used for gout, but its most active component, [[caffeic acid]], is only a weak inhibitor of xanthine oxidase.

{{Enzyme inhibition}}
{{Antigout preparations}}
{{Purinergics}}

{{二次利用|date=10 December 2023}}
[[Category:Xanthine oxidase inhibitors| ]]
[[Category:Uric acid]]
</translate>