https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AZinc%2F111%2FenTranslations:Zinc/111/en - Revision history2026-07-08T17:52:19ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Zinc/111/en&diff=141295&oldid=prevFuzzyBot: Importing a new version from external source2024-04-20T07:29:56Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>In the [[brain]], zinc is stored in specific [[synaptic vesicles]] by [[glutamatergic]] [[neuron]]s and can modulate neuronal excitability. It plays a key role in [[synaptic plasticity]] and so in learning. Zinc [[homeostasis]] also plays a critical role in the functional regulation of the [[central nervous system]]. Dysregulation of zinc homeostasis in the central nervous system that results in excessive synaptic zinc concentrations is believed to induce [[neurotoxicity]] through mitochondrial oxidative stress (e.g., by disrupting certain enzymes involved in the [[electron transport chain]], including [[complex I]], [[complex III]], and [[α-ketoglutarate dehydrogenase]]), the dysregulation of calcium homeostasis, glutamatergic neuronal [[excitotoxicity]], and interference with intraneuronal [[signal transduction]]. L- and D-histidine facilitate brain zinc uptake. [[SLC30A3]] is the primary [[Solute carrier family#Solute carrier family 30|zinc transporter]] involved in cerebral zinc homeostasis.</div>FuzzyBot