https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AVitamin_D%2F101%2Fen 2026-05-12T14:47:40Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Vitamin_D/101/en&diff=110226&oldid=prev 2024-01-25T23:41:41Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>=== Difference between substrates ===<br /> Vitamin{{nbsp}}D&lt;sub&gt;2&lt;/sub&gt; (ergocalciferol) and vitamin{{nbsp}}D&lt;sub&gt;3&lt;/sub&gt; (cholecalciferol) share a similar mechanism of action as outlined above. Metabolites produced by vitamin D&lt;sub&gt;2&lt;/sub&gt; are named with an &#039;&#039;er-&#039;&#039; or &#039;&#039;ergo-&#039;&#039; prefix to differentiate them from the D&lt;sub&gt;3&lt;/sub&gt;-based counterparts (sometimes with a &#039;&#039;chole-&#039;&#039; prefix).<br /> * Metabolites produced from vitamin{{nbsp}}D&lt;sub&gt;2&lt;/sub&gt; tend to bind less well to the vitamin D-binding protein.<br /> * Vitamin{{nbsp}}D&lt;sub&gt;3&lt;/sub&gt; can alternatively be hydroxylated to calcifediol by [[sterol 27-hydroxylase]] (CYP27A1), but vitamin{{nbsp}}D&lt;sub&gt;2&lt;/sub&gt; cannot.<br /> * Ergocalciferol can be directly hydroxylated at position 24 by [[CYP27A1]]. This hydroxylation also leads to a greater degree of inactivation: the activity of calcitriol decreases to 60% of original after 24-hydroxylation, whereas ercalcitriol undergoes a 10-fold decrease in activity on conversion to ercalcitetrol.</div>

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