https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AVitamin_B12%2F72%2FenTranslations:Vitamin B12/72/en - Revision history2026-09-18T05:24:57ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Vitamin_B12/72/en&diff=135266&oldid=prevFuzzyBot: Importing a new version from external source2024-04-05T11:15:36Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>=== Cellular reprogramming ===<br />
Vitamin B<sub>12</sub> through its involvement in one-carbon metabolism plays a key role in [[Induced pluripotent stem cell|cellular reprogramming]] and tissue regeneration and epigenetic regulation. Cellular reprogramming is the process by which somatic cells can be converted to a pluripotent state. Vitamin B<sub>12</sub> levels affect the histone modification [[H3K36me3]], which suppresses illegitimate transcription outside of [[Promoter (genetics)|gene promoters]]. Mice undergoing in vivo reprogramming were found to become depleted in B<sub>12</sub> and show signs of [[methionine]] starvation while supplementing reprogramming mice and cells with B<sub>12</sub> increased reprogramming efficiency, indicating a cell-intrinsic effect.</div>FuzzyBot