https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AVitamin_B12%2F69%2FenTranslations:Vitamin B12/69/en - Revision history2026-05-08T17:58:44ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Vitamin_B12/69/en&diff=135263&oldid=prevFuzzyBot: Importing a new version from external source2024-04-05T11:15:36Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>After the IF/B<sub>12</sub> complex binds to cubam the complex is disassociated and the free vitamin is transported into the [[portal circulation]]. The vitamin is then transferred to TC2, which serves as the circulating plasma transporter, Hereditary defects in production of TC2 and its receptor may produce functional deficiencies in B<sub>12</sub> and infantile [[megaloblastic anemia]], and abnormal B<sub>12</sub> related biochemistry, even in some cases with normal blood B<sub>12</sub> levels. For the vitamin to serve inside cells, the TC2-B<sub>12</sub> complex must bind to a cell receptor protein and be [[endocytosis|endocytosed]]. TC2 is degraded within a [[lysosome]], and free B<sub>12</sub> is released into the cytoplasm, where it is transformed into the bioactive coenzyme by cellular enzymes.</div>FuzzyBot