https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AVitamin_B12%2F65%2FenTranslations:Vitamin B12/65/en - Revision history2026-08-25T02:02:25ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Vitamin_B12/65/en&diff=135259&oldid=prevFuzzyBot: Importing a new version from external source2024-04-05T11:15:36Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>[[Methylmalonyl-CoA mutase|Methylmalonyl coenzyme A mutase]] (MUT) is an isomerase enzyme which uses the AdoB<sub>12</sub> form and reaction type 1 to convert [[L-methylmalonyl-CoA]] to [[succinyl-CoA]], an important step in the catabolic breakdown of some [[amino acid]]s into succinyl-CoA, which then enters energy production via the [[citric acid cycle]]. This functionality is lost in [[vitamin B12 deficiency|vitamin B<sub>12</sub> deficiency]], and can be measured clinically as an increased serum [[methylmalonic acid]] (MMA) concentration. The MUT function is necessary for proper [[myelin]] synthesis. Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration.</div>FuzzyBot