https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AVitamin_B12%2F54%2Fen 2026-08-15T03:46:16Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Vitamin_B12/54/en&diff=135248&oldid=prev 2024-04-05T11:15:36Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>== Drug interactions ==<br /> ===H&lt;sub&gt;2&lt;/sub&gt;-receptor antagonists and proton-pump inhibitors===<br /> Gastric acid is needed to release vitamin B&lt;sub&gt;12&lt;/sub&gt; from protein for absorption. Reduced secretion of [[gastric acid]] and [[pepsin]], from the use of [[H2 antagonist|H&lt;sub&gt;2&lt;/sub&gt; blocker]] or [[proton-pump inhibitor]] (PPI) drugs, can reduce absorption of protein-bound (dietary) vitamin B&lt;sub&gt;12&lt;/sub&gt;, although not of supplemental vitamin B&lt;sub&gt;12&lt;/sub&gt;. H&lt;sub&gt;2&lt;/sub&gt;-receptor antagonist examples include [[cimetidine]], [[famotidine]], [[nizatidine]], and [[ranitidine]]. PPIs examples include [[omeprazole]], [[lansoprazole]], [[rabeprazole]], [[pantoprazole]], and [[esomeprazole]]. Clinically significant vitamin B&lt;sub&gt;12&lt;/sub&gt; deficiency and megaloblastic anemia are unlikely, unless these drug therapies are prolonged for two or more years, or if in addition the person&#039;s dietary intake is below recommended levels. Symptomatic vitamin deficiency is more likely if the person is rendered [[achlorhydria|achlorhydric]] (a complete absence of gastric acid secretion), which occurs more frequently with proton pump inhibitors than H&lt;sub&gt;2&lt;/sub&gt; blockers.</div>

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