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2024-04-10T05:55:07Z

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#The carbanion of the TPP ylid [[nucleophilic attack|nucleophilically attacks]] the carbonyl group on the substrate. (This forms a single bond between the TPP and the substrate.)
#The target bond on the substrate is broken, and its electrons are pushed towards the TPP. This creates a double bond between the substrate carbon and the TPP carbon and pushes the electrons in the N-C double bond in TPP entirely onto the nitrogen atom, reducing it from a positive to neutral form.
#In what is essentially the reverse of step two, the electrons push back in the opposite direction forming a new bond between the substrate carbon and another atom. (In the case of the decarboxylases, this creates a new carbon-hydrogen bond. In the case of transketolase, this attacks a new substrate molecule to form a new carbon-carbon bond.)
#In what is essentially the reverse of step one, the TPP-substrate bond is broken, reforming the TPP ylid and the substrate carbonyl.

[[File:TPP Mechanism.svg|TPP Mechanism]]

Translations:Thiamine pyrophosphate/9/en - Revision history

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