https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AThiamine%2F33%2FenTranslations:Thiamine/33/en - Revision history2026-07-12T17:51:02ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Thiamine/33/en&diff=117060&oldid=prevFuzzyBot: Importing a new version from external source2024-02-19T02:12:10Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>===Industrial synthesis===<br />
[[File:Grewe diamine.svg|thumb|Diamine used in the manufacture of thiamine]]<br />
[[Merck & Co.]] adapted the 1936 laboratory-scale synthesis, allowing them to manufacture thiamine in [[Rahway]] in 1937. However, an alternative route using the intermediate Grewe [[diamine]] (5-(aminomethyl)-2-methyl-4-pyrimidinamine), first published in 1937, was investigated by [[Hoffman La Roche]] and competitive manufacturing processes followed. Efficient routes to the diamine have continued to be of interest. In the [[European Economic Area]], thiamine is registered under [[Registration, Evaluation, Authorisation and Restriction of Chemicals|REACH regulation]] and between 100 and 1,000 tonnes per annum are manufactured or imported there.</div>FuzzyBot