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<p><b>New page</b></p><div>The enzymes transketolase, pyruvate dehydrogenase (PDH), and 2-oxoglutarate dehydrogenase (OGDH) are important in [[carbohydrate metabolism]]. PDH links glycolysis to the [[citric acid cycle]]. OGDH catalyzes the overall conversion of [[Alpha-Ketoglutaric acid|2-oxoglutarate]] (alpha-ketoglutarate) to [[succinyl-CoA]] and CO<sub>2</sub> during the [[citric acid cycle]]. The reaction catalyzed by OGDH is a rate-limiting step in the citric acid cycle. The cytosolic enzyme transketolase is central to the [[pentose phosphate pathway]], a major route for the biosynthesis of the pentose [[sugar]]s [[deoxyribose]] and [[ribose]]. The mitochondrial PDH and OGDH are part of biochemical pathways that result in the generation of [[adenosine triphosphate]] (ATP), which is the main energy transfer molecule for the cell. In the nervous system, PDH is also involved in the synthesis of [[myelin]] and the neurotransmitter [[acetylcholine]].</div>FuzzyBot