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	<title>Translations:Sulfonylurea/24/en - Revision history</title>
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	<updated>2026-09-14T19:22:38Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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		<title>FuzzyBot: Importing a new version from external source</title>
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		<updated>2024-03-12T11:35:57Z</updated>

		<summary type="html">&lt;p&gt;Importing a new version from external source&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;Sulfonylureas bind to and close [[ATP-sensitive potassium channel|ATP-sensitive K&amp;lt;sup&amp;gt;+&amp;lt;/sup&amp;gt;]] (K&amp;lt;sub&amp;gt;ATP&amp;lt;/sub&amp;gt;) channels on the cell membrane of pancreatic [[beta cell]]s, which depolarizes the cell by preventing potassium from exiting. This [[depolarization]] opens voltage-gated [[calcium|Ca]]&amp;lt;sup&amp;gt;2+&amp;lt;/sup&amp;gt; channels. The rise in intracellular calcium leads to increased fusion of [[insulin]] granules with the cell membrane, and therefore increased [[Insulin#Synthesis|secretion]] of mature insulin.&lt;/div&gt;</summary>
		<author><name>FuzzyBot</name></author>
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