https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ARiboflavin%2F16%2Fen 2026-05-26T16:43:55Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Riboflavin/16/en&diff=117301&oldid=prev 2024-02-19T07:27:20Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>==Synthesis==<br /> ===Biosynthesis===<br /> Biosynthesis takes place in bacteria, fungi and plants, but not animals. The biosynthetic precursors to riboflavin are [[ribulose 5-phosphate]] and [[guanosine triphosphate]]. The former is converted to L-3,4-dihydroxy-2-butanone-4-phosphate while the latter is transformed in a series of reactions that lead to 5-amino-6-(D-ribitylamino)uracil. These two compounds are then the substrates for the penultimate step in the pathway, catalysed by the enzyme [[lumazine synthase]] in reaction {{EC number|2.5.1.78}}.<br /> :[[File:Lumazine synthase reaction.svg|650px]]<br /> In the final step of the biosynthesis, two molecules of [[6,7-dimethyl-8-ribityllumazine]] are combined by the enzyme [[riboflavin synthase]] in a [[dismutation]] reaction. This generates one molecule of riboflavin and one of 5-amino-6-(D-ribitylamino) uracil. The latter is recycled to the previous reaction in the sequence.<br /> :[[File:Riboflavin synthase dismutation.svg|650px]]<br /> Conversions of riboflavin to the [[Cofactor (biochemistry)|cofactors]] FMN and FAD are carried out by the enzymes [[riboflavin kinase]] and [[FMN adenylyltransferase|FAD synthetase]] acting sequentially.<br /> :[[File:FAD Synthesis.png|thumb|Riboflavin is the biosynthetic precursor of FMN and FAD]]</div>

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