https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ARenin%E2%80%93angiotensin_system%2F8%2Fen 2026-09-14T10:59:17Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Renin%E2%80%93angiotensin_system/8/en&diff=131395&oldid=prev 2024-03-27T00:15:47Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div># If the perfusion of the [[juxtaglomerular apparatus]] in the kidney&#039;s [[macula densa]] decreases, then the juxtaglomerular cells (granular cells, modified pericytes in the glomerular capillary) release the [[enzyme]] [[renin]].<br /> # Renin [[Proteolysis#Cleavage of precursor proteins|cleaves]] a [[Peptide#Notes on terminology|decapeptide]] from [[angiotensinogen]], a [[globular protein]]. The decapeptide is known as [[Angiotensin#Angiotensin I|angiotensin I]].<br /> # Angiotensin I is then converted to an [[Peptide#Notes on terminology|octapeptide]], &#039;&#039;[[angiotensin|angiotensin II]]&#039;&#039; by [[angiotensin-converting enzyme]] (ACE), which is thought to be found mainly in endothelial cells of the [[capillary|capillaries]] throughout the body, within the lungs and the epithelial cells of the kidneys. One study in 1992 found ACE in all blood vessel endothelial cells.<br /> # Angiotensin II is the major bioactive product of the renin–angiotensin system, binding to receptors on [[intraglomerular mesangial cells]], causing these cells to contract along with the blood vessels surrounding them; and to receptors on the zona glomerulosa cells, causing the release of [[aldosterone]] from the [[zona glomerulosa]] in the [[adrenal cortex]]. Angiotensin II acts as an [[endocrine system|endocrine]], [[autocrine signalling|autocrine]]/[[paracrine signalling|paracrine]], and [[intracrine]] hormone.</div>

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