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2024-04-03T12:34:50Z

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Pyridoxal phosphate has numerous roles in human body. A few examples below:
* '''[[Metabolism]] and [[biosynthesis]] of [[serotonin]]'''. Pyridoxal phosphate is a [[Cofactor (biochemistry)|cofactor]] of [[Aromatic L-amino acid decarboxylase|aromatic L-amino acids decarboxylase]]. This allows for conversion of [[5-Hydroxytryptophan|5-hydroxytryptophan]] (5-HTP) into serotonine (5-HT). This reaction takes place in serotonergic neurons.
* '''Metabolism and biosynthesis of [[histamine]].''' Pyridoxal phosphate is a cofactor of [[Histidine decarboxylase|L-histidine decarboxylase]]. This allows for conversion of [[histidine]] into histamine. This reaction takes place in [[Golgi apparatus]] in [[mast cell]]s and in [[basophil]]s. Next, histamine is stored in granularity in mast cells as a complex with acid residues of [[heparin]] proteoglycan while in basophils as a complex with chondroitine sulfate.
* '''Metabolism and biosynthesis of [[Gamma-Aminobutyric acid|GABA]] (γ-aminobutyric acid)'''. Pyridoxal phosphate is a cofactor of glutamic acid decarboxylase (GAD). This allows for conversion of glutamate into GABA. Reaction takes place in cytoplasm of termination of GABA-ergic neurons, therefore [[Vitamin B6|vitamin B<sub>6</sub>]] deficiency may cause epileptic [[Epileptic seizure|seizures]] in children. Pyridoxal phosphate also participates in the oxidative [[Deamidation|deamination]] of GABA, where it is a cofactor of GABA aminotransferase.
* '''Metabolism of [[ornithine]]'''. Pyridoxal phosphate is a cofactor of ornithine carboxylase.
* '''[[Transamination]].''' Pyridoxal phosphate takes part in [[decomposition]] and synthesis of [[amino acid]]s, fats, and carbohydrates, and in the biosynthesis of hormones, neurotransmitters, and heme.

Translations:Pyridoxal phosphate/9/en - Revision history

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