https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ANifedipine%2F6%2FenTranslations:Nifedipine/6/en - Revision history2026-08-24T03:55:58ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Nifedipine/6/en&diff=76371&oldid=prevFuzzyBot: Importing a new version from external source2023-11-15T12:36:47Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>Nifedipine given as [[sublingual administration]] has previously been used in [[Hypertensive emergency|hypertensive emergencies]]. It was once frequently prescribed on an as-needed basis to patients taking [[Monoamine oxidase inhibitor|MAOIs]] for real or perceived hypertensive crises. This was found to be dangerous, and has been abandoned. Sublingual administration of nifedipine promotes a hypotensive effect via peripheral vasodilation. It can cause an uncontrollable decrease in blood pressure, [[Tachycardia|reflex tachycardia]], and a ''steal phenomenon'' in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including [[Brain ischemia|cerebral ischemia/infarction]], [[myocardial infarction]], complete [[heart block]], and death. As a result of this, in 1985 the [[Food and Drug Administration|FDA]] reviewed all data regarding the safety and effectiveness of sublingual nifedipine for the management of hypertensive emergencies, and concluded that the practice should be abandoned because it was neither safe nor effective. An exception to the avoidance of this practice is in the use of nifedipine for the treatment of hypertension associated with [[autonomic dysreflexia]] in [[spinal cord injury]].</div>FuzzyBot