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Niacin is also a prescription medication. Amounts far in excess of the recommended dietary intake for vitamin functions will lower blood [[triglyceride]]s and [[low-density lipoprotein|low density lipoprotein cholesterol]] (LDL-C), and raise blood [[high density lipoprotein|high density lipoprotein cholesterol]] (HDL-C, often referred to as "good" cholesterol). There are two forms: immediate-release and sustained-release niacin. Initial prescription amounts are 500 mg/day, increased over time until a therapeutic effect is achieved. Immediate-release doses can be as high as 3,000 mg/day; sustained-release as high as 2,000 mg/day. Despite the proven lipid changes, niacin has not been found useful for decreasing the risk of [[cardiovascular disease]] in those already on a [[statin]]. A 2010 review had concluded that niacin was effective as a mono-therapy, but a 2017 review incorporating twice as many trials concluded that prescription niacin, while affecting lipid levels, did not reduce all-cause mortality, cardiovascular mortality, myocardial infarctions, nor fatal or non-fatal strokes. Prescription niacin was shown to cause hepatotoxicity and increase risk of [[type 2 diabetes]]. Niacin prescriptions in the U.S. had peaked in 2009, at 9.4{{nbsp}}million, declining to 800{{nbsp}}thousand by 2020.

Translations:Niacin/11/en - Revision history

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