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In 1967, Avogadro, Crepaldi and coworkers described six moderately obese people with diabetes, [[hypercholesterolemia]], and marked [[hypertriglyceridemia]], all of which improved when the affected people were put on a hypocaloric, low-carbohydrate diet.
In 1977, Haller used the term ''metabolic syndrome'' for associations of obesity, diabetes mellitus, [[hyperlipoproteinemia]], [[hyperuricemia]], and [[hepatic steatosis]] when describing the additive effects of risk factors on atherosclerosis.
The same year, Singer used the term for associations of obesity, gout, diabetes mellitus, and hypertension with hyperlipoproteinemia.
In 1977 and 1978, Gerald B. Phillips developed the concept that risk factors for [[myocardial infarction]] concur to form a "constellation of abnormalities" (i.e., [[glucose intolerance]], [[hyperinsulinemia]], [[hypercholesterolemia]], [[hypertriglyceridemia]], and hypertension) associated not only with heart disease, but also with aging, obesity and other clinical states. He suggested there must be an underlying linking factor, the identification of which could lead to the prevention of cardiovascular disease; he hypothesized that this factor was [[sex hormones]].
In 1988, in his [[Banting Lectures|Banting lecture]], [[Gerald M. Reaven]] proposed insulin resistance as the underlying factor and named the constellation of abnormalities syndrome X. Reaven did not include abdominal obesity, which has also been hypothesized as the underlying factor, as part of the condition.

Translations:Metabolic syndrome/44/en - Revision history

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