FuzzyBot: Importing a new version from external source

2024-02-23T13:30:13Z

Importing a new version from external source

New page

===Signaling===
Evidence has emerged showing that [[lipid signaling]] is a vital part of the [[cell signaling]]. Lipid signaling may occur via activation of [[G protein-coupled receptor|G protein-coupled]] or [[nuclear receptor]]s, and members of several different lipid categories have been identified as signaling molecules and [[Second messenger system|cellular messengers]]. These include [[sphingosine-1-phosphate]], a sphingolipid derived from ceramide that is a potent messenger molecule involved in regulating calcium mobilization, cell growth, and apoptosis; [[diacylglycerol]] and the [[phosphatidylinositol]] phosphates (PIPs), involved in calcium-mediated activation of [[protein kinase C]]; the [[prostaglandins]], which are one type of fatty-acid derived eicosanoid involved in [[inflammation]] and [[immunity (medical)|immunity]]; the steroid hormones such as [[estrogen]], [[testosterone]] and [[cortisol]], which modulate a host of functions such as reproduction, metabolism and blood pressure; and the [[oxysterol]]s such as 25-hydroxy-cholesterol that are [[liver X receptor]] [[agonist]]s. Phosphatidylserine lipids are known to be involved in signaling for the phagocytosis of apoptotic cells or pieces of cells. They accomplish this by being exposed to the extracellular face of the cell membrane after the inactivation of [[flippase]]s which place them exclusively on the cytosolic side and the activation of scramblases, which scramble the orientation of the phospholipids. After this occurs, other cells recognize the phosphatidylserines and phagocytosize the cells or cell fragments exposing them.

Translations:Lipid/38/en - Revision history

FuzzyBot: Importing a new version from external source