https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ALevomefolic_acid%2F3%2Fen 2026-09-14T04:08:51Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Levomefolic_acid/3/en&diff=135125&oldid=prev 2024-04-05T10:16:16Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Levomefolic acid&#039;&#039;&#039; ([[International Nonproprietary Name|INN]], also known as &#039;&#039;&#039;L-5-MTHF&#039;&#039;&#039;, &#039;&#039;&#039;&lt;small&gt;L&lt;/small&gt;-methylfolate&#039;&#039;&#039; and &#039;&#039;&#039;&lt;small&gt;L&lt;/small&gt;-5-methyltetrahydrofolate&#039;&#039;&#039; and &#039;&#039;&#039;(6&#039;&#039;S&#039;&#039;)-5-methyltetrahydrofolate&#039;&#039;&#039;, and &#039;&#039;&#039;(6&#039;&#039;S&#039;&#039;)-5-MTHF&#039;&#039;&#039;) is the primary biologically active form of [[folate]] used at the cellular level for [[DNA]] reproduction, the [[cysteine]] cycle and the regulation of [[homocysteine]]. It is also the form found in circulation and transported across membranes into tissues and across the [[blood–brain barrier]]. In the cell, &lt;small&gt;L&lt;/small&gt;-methylfolate is used in the [[methylation]] of homocysteine to form [[methionine]] and [[tetrahydrofolate]] (THF). THF is the immediate acceptor of one carbon unit for the synthesis of [[thymidine]]-DNA, [[purine]]s (RNA and DNA) and methionine. The un-methylated form, [[folic acid]] (vitamin B&lt;sub&gt;9&lt;/sub&gt;), is a synthetic form of folate, and must undergo enzymatic reduction by [[dihydrofolate reductase]] (DHFR) to become biologically active.</div>

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