https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AInsulin_analog%2F13%2FenTranslations:Insulin analog/13/en - Revision history2026-05-26T10:49:46ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Insulin_analog/13/en&diff=130149&oldid=prevFuzzyBot: Importing a new version from external source2024-03-19T08:49:44Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>==Modifications==<br />
Before biosynthetic human [[Recombinant DNA|recombinant]] analogues were available, porcine insulin was chemically converted into human insulin. Chemical modifications of the amino acid side chains at the [[N-terminus]] and/or the [[C-terminus]] were made in order to alter the [[ADME]] characteristics of the analogue. Semisynthetic insulins were clinically used for some time based on chemical modification of animal insulins, for example [[Novo Nordisk]] enzymatically converted porcine insulin into semisynthetic 'human' insulin by removing the single amino acid that varies from the human variety, and chemically adding the human amino acid.</div>FuzzyBot