https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AInsulin%2F50%2FenTranslations:Insulin/50/en - Revision history2026-05-26T07:25:36ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Insulin/50/en&diff=129904&oldid=prevFuzzyBot: Importing a new version from external source2024-03-18T07:33:31Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>=== Regulator of endocannabinoid metabolism ===<br />
Insulin is a major regulator of [[Endocannabinoids|endocannabinoid]] (EC) [[metabolism]] and insulin treatment has been shown to reduce [[intracellular]] ECs, the [[2-Arachidonoylglycerol|2-arachidonoylglycerol]] (2-AG) and [[anandamide]] (AEA), which correspond with insulin-sensitive expression changes in enzymes of EC metabolism. In insulin-resistant [[adipocyte]]s, patterns of insulin-induced enzyme expression is disturbed in a manner consistent with elevated EC [[Biosynthesis|synthesis]] and reduced EC degradation. Findings suggest that [[Insulin resistance|insulin-resistant]] adipocytes fail to regulate EC metabolism and decrease intracellular EC levels in response to insulin stimulation, whereby [[Obesity|obese]] insulin-resistant individuals exhibit increased concentrations of ECs. This dysregulation contributes to excessive [[Adipose tissue|visceral fat]] accumulation and reduced [[adiponectin]] release from abdominal adipose tissue, and further to the onset of several cardiometabolic risk factors that are associated with obesity and [[type 2 diabetes]].</div>FuzzyBot