https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AInsulin%2F49%2FenTranslations:Insulin/49/en - Revision history2026-05-22T08:14:04ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Insulin/49/en&diff=129903&oldid=prevFuzzyBot: Importing a new version from external source2024-03-18T07:33:31Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>=== Degradation ===<br />
Once an insulin molecule has docked onto the receptor and effected its action, it may be released back into the extracellular environment, or it may be degraded by the cell. The two primary sites for insulin clearance are the liver and the kidney. It is broken down by the enzyme, [[protein-disulfide reductase (glutathione)]], which breaks the disulphide bonds between the A and B chains. The liver clears most insulin during first-pass transit, whereas the kidney clears most of the insulin in systemic circulation. Degradation normally involves [[endocytosis]] of the insulin-receptor complex, followed by the action of [[insulin-degrading enzyme]]. An insulin molecule produced endogenously by the beta cells is estimated to be degraded within about one hour after its initial release into circulation (insulin [[biological half-life|half-life]] ~ 4–6&nbsp;minutes).</div>FuzzyBot