https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AInsulin%2F38%2FenTranslations:Insulin/38/en - Revision history2026-11-11T03:41:15ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Insulin/38/en&diff=129892&oldid=prevFuzzyBot: Importing a new version from external source2024-03-18T07:33:31Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>Even during digestion, in general, one or two hours following a meal, insulin release from the pancreas is not continuous, but [[oscillates]] with a period of 3–6&nbsp;minutes, changing from generating a blood insulin concentration more than about 800 [[pico-|p]] [[unit mole|mol]]/l to less than 100 pmol/L (in rats). This is thought to avoid [[receptor downregulation|downregulation]] of [[insulin receptor]]s in target cells, and to assist the liver in extracting insulin from the blood. This oscillation is important to consider when administering insulin-stimulating medication, since it is the oscillating blood concentration of insulin release, which should, ideally, be achieved, not a constant high concentration. This may be achieved by [[Pulsatile insulin|delivering insulin rhythmically]] to the [[portal vein]], by light activated delivery, or by [[islet cell transplantation]] to the liver.</div>FuzzyBot