https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AInsulin%2F13%2FenTranslations:Insulin/13/en - Revision history2026-09-17T13:30:07ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Insulin/13/en&diff=129867&oldid=prevFuzzyBot: Importing a new version from external source2024-03-18T07:33:31Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>[[NeuroD1]], also known as β2, regulates insulin exocytosis in pancreatic [[β cells]] by directly inducing the expression of [[genes]] involved in exocytosis. It is localized in the [[cytosol]], but in response to high [[glucose]] it becomes [[glycosylated]] by [[OGT (gene)|OGT]] and/or [[phosphorylated]] by [[Extracellular signal-regulated kinases|ERK]], which causes translocation to the nucleus. In the nucleus β2 heterodimerizes with [[TCF3|E47]], binds to the E1 element of the insulin promoter and recruits co-activator [[EP300|p300]] which acetylates β2. It is able to interact with other transcription factors as well in activation of the insulin gene.</div>FuzzyBot