https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AInsulin%2F10%2Fen 2026-11-11T03:41:15Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Insulin/10/en&diff=129864&oldid=prev 2024-03-18T07:33:31Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>== Production ==<br /> [[File:Insulin gene activation.png|thumb|upright=1.8|Diagram of insulin regulation upon high blood glucose]]<br /> Insulin is produced exclusively in the beta cells of the [[pancreatic islet]]s in mammals, and the Brockmann body in some fish. Human insulin is produced from the &#039;&#039;INS&#039;&#039; [[gene]], located on chromosome 11. Rodents have two functional insulin genes; one is the homolog of most mammalian genes (&#039;&#039;Ins2&#039;&#039;), and the other is a retroposed copy that includes promoter sequence but that is missing an intron (&#039;&#039;Ins1&#039;&#039;). [[Transcription (biology)|Transcription]] of the insulin gene increases in response to elevated blood glucose. This is primarily controlled by [[transcription factor]]s that bind [[Enhancer (genetics)|enhancer sequences]] in the ~400 [[base pair]]s before the gene&#039;s transcription start site.</div>

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