https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AHypertension%2F17%2FenTranslations:Hypertension/17/en - Revision history2026-08-21T04:44:30ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Hypertension/17/en&diff=123460&oldid=prevFuzzyBot: Importing a new version from external source2024-02-29T13:03:01Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>===Primary hypertension===<br />
{{Main|Essential hypertension}}<br />
Hypertension results from a complex interaction of [[Gene|genes]] and environmental factors. Numerous common genetic variants with small effects on blood pressure have been identified as well as some rare genetic variants with large effects on blood pressure. Also, [[Genome-wide association study|genome-wide association studies (GWAS)]] have identified 35 genetic loci related to blood pressure; 12 of these genetic loci influencing blood pressure were newly found. Sentinel [[Single-nucleotide polymorphism|SNP]] for each new genetic locus identified has shown an association with [[DNA methylation]] at multiple nearby [[CpG site]]s. These sentinel SNP are located within genes related to vascular smooth muscle and renal function. DNA methylation might affect in some way linking common genetic variation to multiple [[phenotype]]s even though mechanisms underlying these associations are not understood. Single variant test performed in this study for the 35 sentinel SNP (known and new) showed that genetic variants singly or in aggregate contribute to risk of clinical phenotypes related to high blood pressure.</div>FuzzyBot