https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AHydroxocobalamin%2F18%2FenTranslations:Hydroxocobalamin/18/en - Revision history2026-09-09T19:44:43ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Hydroxocobalamin/18/en&diff=136170&oldid=prevFuzzyBot: Importing a new version from external source2024-04-07T01:35:05Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>Cobalamins are characterized by a [[porphyrin]]-like [[corrin]] nucleus that contains a single [[cobalt]] atom bound to a [[benzimidazole|benzimidazolyl]] [[nucleotide]] and a variable residue (R) group. The variable R group gives rise to the four most commonly known cobalamins: [[cyanocobalamin|CNCbl]], [[methylcobalamin]], [[cobamamide|5-deoxyadenosylcobalamin]], and OHCbl. In the serum, hydroxocobalamin and cyanocobalamin are believed to function as storage or transport forms of the molecule, whereas methylcobalamin and 5-deoxyadenosylcobalamin are the active forms of the coenzyme required for cell growth and replication. Cyanocobalamin is usually converted to hydroxocobalamin in the serum, whereas hydroxocobalamin is converted to either methylcobalamin or 5-deoxyadenosyl cobalamin. Cobalamins circulate bound to serum proteins called [[transcobalamins]] (TC) and [[haptocorrin]]s. Hydroxocobalamin has a higher affinity to the TC II transport protein than cyanocobalamin, or 5-deoxyadenosylcobalamin. From a [[biochemical]] point of view, two essential enzymatic reactions require vitamin B<sub>12</sub> (cobalamin).</div>FuzzyBot