https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AHydroxocobalamin%2F17%2FenTranslations:Hydroxocobalamin/17/en - Revision history2026-07-11T04:30:56ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Hydroxocobalamin/17/en&diff=136169&oldid=prevFuzzyBot: Importing a new version from external source2024-04-07T01:35:05Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>==Mechanism of action==<br />
Vitamin B<sub>12</sub> refers to a group of compounds called cobalamins that are available in the human body in a variety of mostly interconvertible forms. Together with [[folate]], cobalamins are essential cofactors required for [[DNA]] synthesis in cells where [[chromosomal]] replication and division are occurring—most notably the [[bone marrow]] and [[myeloid]] cells. As a [[Cofactor (biochemistry)|cofactor]], cobalamins are essential for two cellular reactions:<br />
*the mitochondrial [[methylmalonyl-CoA mutase]] conversion of [[methylmalonic acid]] (MMA) to [[succinate]], which links lipid and carbohydrate metabolism, and<br />
*the activation of [[methionine synthase]], which is the rate-limiting step in the synthesis of [[methionine]] from [[homocysteine]] and [[5-methyltetrahydrofolate]].</div>FuzzyBot