https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AGlucagon-like_peptide-1%2F20%2FenTranslations:Glucagon-like peptide-1/20/en - Revision history2026-05-28T04:41:11ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Glucagon-like_peptide-1/20/en&diff=127247&oldid=prevFuzzyBot: Importing a new version from external source2024-03-11T00:48:14Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>Additionally, GLP-1 ensures the β cell insulin stores are replenished to prevent exhaustion during secretion by promoting insulin gene transcription, [[mRNA]] stability and biosynthesis. GLP-1 evidently also increases β cell mass by promoting proliferation and neogenesis while inhibiting [[apoptosis]]. As both type 1 and 2 diabetes are associated with reduction of functional β cells, this effect is highly interesting regarding diabetes treatment. Considered almost as important as the effect of enhancing insulin secretion, GLP-1 has been shown to inhibit glucagon secretion at glucose levels above fasting levels. Critically, this does not affect the glucagon response to [[hypoglycemia]] as this effect is also glucose-dependent. The inhibitory effect is presumably mediated indirectly through [[somatostatin]] secretion, but a direct effect cannot be completely excluded.</div>FuzzyBot