https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AGlucagon-like_peptide-1%2F16%2FenTranslations:Glucagon-like peptide-1/16/en - Revision history2026-09-14T22:37:21ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Glucagon-like_peptide-1/16/en&diff=127243&oldid=prevFuzzyBot: Importing a new version from external source2024-03-11T00:48:14Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>[[Neutral endopeptidase]] 24.11 (NEP 24.11) is a membrane-bound zinc metallopeptidase widely expressed in several tissues, but found in particularly high concentrations in the [[kidneys]], which is also identified accountable for the rapid degradation of GLP-1. It primarily cleaves peptides at the [[N-terminal]] side of [[aromatic amino acids]] or [[hydrophobic]] [[amino acids]] and is estimated to contribute by up to 50% of the GLP-1 degradation. However, the activity only becomes apparent once the degradation of [[DPP-4]] has been prevented, as the majority of GLP-1 reaching the [[kidneys]] have already been processed by [[DPP-4]]. Similarly, [[renal clearance]] appear more significant for the elimination of already inactivated GLP-1.</div>FuzzyBot