https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AGlucagon-like_peptide-1%2F11%2FenTranslations:Glucagon-like peptide-1/11/en - Revision history2026-09-14T23:24:09ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Glucagon-like_peptide-1/11/en&diff=127238&oldid=prevFuzzyBot: Importing a new version from external source2024-03-11T00:48:14Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>GLP-1 is released in a [[phase (pharmacology)|biphasic]] pattern with an early phase after 10–15 minutes followed by a longer second phase after 30–60 minutes upon meal ingestion. As the majority of L-cells are located in the distal [[ileum]] and colon, the early phase is likely explained by neural signalling, gut peptides or [[neurotransmitters]]. Other evidence suggest that the amount of L-cells located in the proximal [[jejunum]] is sufficient to account for the early phase secretion through direct contact with luminal nutrients. Less controversially, the second phase is likely caused by direct stimulation of L-cells by digested [[nutrients]]. The rate of [[gastric emptying]] is therefore an important aspect to consider, as it regulates the entry of nutrients into the [[small intestines]] where the direct stimulation occurs. One of the actions of GLP-1 is to inhibit [[gastric emptying]], thus slowing down its own [[secretion]] upon [[postprandial]] activation.</div>FuzzyBot