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&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;==Indications==&lt;br /&gt;
===Type 2 diabetes===&lt;br /&gt;
GLP-1 agonists were developed initially for [[type 2 diabetes]]. The 2022 [[American Diabetes Association]] (ADA) standards of medical care in diabetes include GLP-1 agonist or [[SGLT2 inhibitor]] as a first line [[pharmacological therapy]] for type 2 diabetes in patients who have or are at high risk for [[atherosclerotic cardiovascular disease]] or [[heart failure]]. They are also a first line treatment for people with both type 2 diabetes and kidney disease. Both types of medication can be combined with [[metformin]]. One of the advantages of GLP-1 agonists over older [[anti-diabetic medication#Secretagogues|insulin secretagogues]], such as [[sulfonylurea]]s or [[meglitinide]]s, is that they have a lower risk of causing [[hypoglycemia]]. The ADA also recommends use of GLP-1 agonists instead of starting insulin in people with type 2 diabetes who need additional glucose control, except where there is catabolism, hyperglycemia above a certain threshold, or autoimmune diabetes is suspected.&lt;/div&gt;</summary>
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