https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AFolinic_acid%2F25%2FenTranslations:Folinic acid/25/en - Revision history2026-05-15T15:43:43ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Folinic_acid/25/en&diff=135035&oldid=prevFuzzyBot: Importing a new version from external source2024-04-05T08:57:52Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>== History ==<br />
Folinic acid was discovered as a needed growth factor for the bacterium ''[[Leuconostoc citrovorum]]'' in 1948, by Sauberlich and Baumann. This resulted in it being called "citrovorum factor," meaning citrovorum growth factor. It had an unknown structure, but was found to be a derivative of folate that had to be metabolized in the liver before it could support growth of ''L. citrovorum.'' The synthesis of citrovorum factor by liver cells in culture was eventually accomplished from pteroylglutamic acid in the presence of suitable concentrations of ascorbic acid. The simultaneous addition of sodium formate to such systems resulted in increased citrovorum factor activity in the cell-free supernatants (producing, as now known, the 5-formyl derivative), and from this method of preparation of large amounts of the factor, its structure as levo-folinic acid (5-formyl tetrahydrofolic acid) was eventually deduced.</div>FuzzyBot