https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AFolinic_acid%2F21%2FenTranslations:Folinic acid/21/en - Revision history2026-09-14T04:39:24ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Folinic_acid/21/en&diff=135031&oldid=prevFuzzyBot: Importing a new version from external source2024-04-05T08:57:52Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>== Mechanism of action ==<br />
Folinic acid is a 5-formyl derivative of [[tetrahydrofolic acid]]. It is readily converted to other reduced folic acid derivatives (e.g., [[5,10-methylenetetrahydrofolate]], [[5-methyltetrahydrofolate]]), thus has vitamin activity equivalent to that of folic acid. Since it does not require the action of [[dihydrofolate reductase]] for its conversion, its function as a vitamin is unaffected by [[enzyme inhibition|inhibition]] of this enzyme by drugs such as methotrexate. This is the classical view of folinic acid rescue therapy. In 1980s, however, folinic acid was found to reactivate the dihydrofolate reductase itself even when methotrexate exists.</div>FuzzyBot