https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AFolate%2F26%2FenTranslations:Folate/26/en - Revision history2026-08-15T03:56:04ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Folate/26/en&diff=134738&oldid=prevFuzzyBot: Importing a new version from external source2024-04-05T04:48:08Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>Some evidence links a shortage of folate with [[clinical depression]]. Limited evidence from [[randomized controlled trials]] showed using folic acid in addition to [[selective serotonin reuptake inhibitor]]s (SSRIs) may have benefits. Research found a link between depression and low levels of folate. The exact mechanisms involved in the development of schizophrenia and depression are not entirely clear, but the bioactive folate, [[Levomefolic acid|methyltetrahydrofolate]] (5-MTHF), a direct target of methyl donors such as [[S-adenosyl methionine]] (SAMe), recycles the inactive [[dihydrobiopterin]] (BH<sub>2</sub>) into [[tetrahydrobiopterin]] (BH<sub>4</sub>), the necessary [[Cofactor (biochemistry)|cofactor]] in various steps of monoamine synthesis, including that of [[dopamine]] and [[serotonin]]. BH<sub>4</sub> serves a regulatory role in monoamine neurotransmission and is required to mediate the actions of most antidepressants.</div>FuzzyBot