https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AFebuxostat%2F16%2FenTranslations:Febuxostat/16/en - Revision history2026-07-08T02:21:42ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Febuxostat/16/en&diff=143000&oldid=prevFuzzyBot: Importing a new version from external source2024-04-22T11:20:39Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>[[File:Febuxostat active metabolites.svg|thumb|right|The [[active metabolite]]s in humans: 67M-1, 67M-2 and 67M-4 (top to bottom)]]<br />
Febuxostat has three active metabolites in humans, which are formed mainly by a number of [[cytochrome P450]] liver enzymes ([[CYP1A1]], [[CYP1A2|1A2]], [[CYP2C8|2C8]], [[CYP2C9|2C9]]). One of them is a [[dicarboxylic acid]], the other two are [[hydroxylated]] derivatives. These, as well as the original drug, are further [[glucuronidated]], mainly by the enzymes [[UGT1A1]], [[UGT1A8|1A8]], and [[UGT1A9|1A9]]. Febuxostat and its metabolites are eliminated via the urine (49% of the total substance, comprising 3% unchanged febuxostat, 30% febuxostat glucuronide, 13% active metabolites and their glucuronides, and 3% unknown entities) and via the faeces (45%, of which 12% unchanged febuxostat, 1% glucuronide, 25% active metabolites and their glucuronides, and 7% unknown entities). [[Elimination half-life]] is five to eight hours.</div>FuzzyBot