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	<title>Translations:Fatty acid/54/en - Revision history</title>
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		<title>FuzzyBot: Importing a new version from external source</title>
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		<updated>2024-02-26T03:26:46Z</updated>

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&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;==Skin==&lt;br /&gt;
The [[stratum corneum]] {{ndash}} the outermost layer of the [[epidermis]] {{ndash}} is composed of terminally [[Cellular differentiation|differentiated]] and [[Enucleation (microbiology)|enucleated]] [[corneocyte]]s within a lipid matrix. Together with [[cholesterol]] and [[ceramide]]s, free fatty acids form a water-impermeable barrier that prevents [[evaporation|evaporative water loss]]. Generally, the epidermal lipid matrix is composed of an equimolar mixture of ceramides (about 50% by weight), cholesterol (25%), and free fatty acids (15%). Saturated fatty acids 16 and 18 carbons in length are the dominant types in the epidermis, while unsaturated fatty acids and saturated fatty acids of various other lengths are also present. The relative abundance of the different fatty acids in the epidermis is dependent on the body site the skin is covering. There are also characteristic epidermal fatty acid alterations that occur in [[psoriasis]], [[atopic dermatitis]], and other [[inflammation|inflammatory conditions]].&lt;/div&gt;</summary>
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