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The "uncombined fatty acids" or "free fatty acids" found in the circulation of animals come from the breakdown (or [[lipolysis]]) of stored triglycerides. Because they are insoluble in water, these fatty acids are transported bound to plasma [[albumin]]. The levels of "free fatty acids" in the blood are limited by the availability of albumin binding sites. They can be taken up from the blood by all cells that have mitochondria (with the exception of the cells of the [[central nervous system]]). Fatty acids can only be broken down in mitochondria, by means of [[beta-oxidation]] followed by further combustion in the [[citric acid cycle]] to CO{{sub|2}} and water. Cells in the central nervous system, although they possess mitochondria, cannot take free fatty acids up from the blood, as the [[blood–brain barrier]] is impervious to most free fatty acids, excluding [[short-chain fatty acid]]s and [[medium-chain fatty acid]]s. These cells have to manufacture their own fatty acids from carbohydrates, as described above, in order to produce and maintain the phospholipids of their cell membranes, and those of their organelles.

Translations:Fatty acid/34/en - Revision history

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