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	<title>Translations:Fatty acid/32/en - Revision history</title>
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	<updated>2026-09-15T17:03:47Z</updated>
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		<title>FuzzyBot: Importing a new version from external source</title>
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		<updated>2024-02-26T03:26:45Z</updated>

		<summary type="html">&lt;p&gt;Importing a new version from external source&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;Carbohydrates are converted into [[Pyruvic acid|pyruvate]] by [[glycolysis]] as the first important step in the conversion of carbohydrates into fatty acids. Pyruvate is then decarboxylated to form [[acetyl-CoA]] in the [[mitochondrion]]. However, this acetyl CoA needs to be transported into [[cytosol]] where the synthesis of fatty acids occurs. This cannot occur directly. To obtain cytosolic acetyl-CoA, [[Citric acid|citrate]] (produced by the condensation of acetyl-CoA with [[Oxaloacetic acid|oxaloacetate]]) is removed from the [[citric acid cycle]] and carried across the inner mitochondrial membrane into the cytosol. There it is cleaved by [[ATP citrate lyase]] into acetyl-CoA and oxaloacetate. The oxaloacetate is returned to the mitochondrion as [[malate]]. The cytosolic acetyl-CoA is carboxylated by [[acetyl-CoA carboxylase]] into [[malonyl-CoA]], the first committed step in the synthesis of fatty acids.&lt;/div&gt;</summary>
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