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Several [[meta-analysis|meta-analyses]] (reviews and consolidations of multiple previously published experimental studies) have confirmed a significant relationship between saturated fat and high [[serum cholesterol]] levels, which in turn have been claimed to have a causal relation with increased risk of cardiovascular disease (the so-called [[lipid hypothesis]]). However, high cholesterol may be caused by many factors. Other indicators, such as high LDL/HDL ratio, have proved to be more predictive. In a study of [[myocardial infarction]] in 52 countries, the [[apolipoprotein B|ApoB]]/[[apolipoprotein A1|ApoA1]] (related to LDL and HDL, respectively) ratio was the strongest predictor of CVD among all risk factors. There are other pathways involving [[obesity]], [[triglyceride]] levels, [[insulin resistance|insulin sensitivity]], [[endothelium|endothelial function]], and [[thrombogenicity]], among others, that play a role in CVD, although it seems, in the absence of an adverse blood lipid profile, the other known risk factors have only a weak [[atherogenic]] effect. Different saturated fatty acids have differing effects on various lipid levels.

Translations:Fat/37/en - Revision history

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