https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AEnzyme%2F100%2FenTranslations:Enzyme/100/en - Revision history2026-09-18T07:22:08ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Enzyme/100/en&diff=118938&oldid=prevFuzzyBot: Importing a new version from external source2024-02-21T10:18:20Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>One example of enzyme deficiency is the most common type of [[phenylketonuria]]. Many different single amino acid mutations in the enzyme [[phenylalanine hydroxylase]], which catalyzes the first step in the degradation of [[phenylalanine]], result in build-up of phenylalanine and related products. Some mutations are in the active site, directly disrupting binding and catalysis, but many are far from the active site and reduce activity by destabilising the protein structure, or affecting correct oligomerisation. This can lead to [[intellectual disability]] if the disease is untreated.<br />
Oral administration of enzymes can be used to treat some functional enzyme deficiencies, such as [[pancreatic insufficiency]] and [[lactose intolerance]].</div>FuzzyBot