https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AEndocrinology%2F32%2FenTranslations:Endocrinology/32/en - Revision history2026-09-17T14:14:27ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Endocrinology/32/en&diff=118028&oldid=prevFuzzyBot: Importing a new version from external source2024-02-20T04:43:06Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>Recent work in endocrinology focuses on the molecular mechanisms responsible for triggering the effects of [[hormone]]s. The first example of such work being done was in 1962 by [[Earl Wilbur Sutherland Jr.|Earl Sutherland]]. Sutherland investigated whether hormones enter cells to evoke action, or stayed outside of cells. He studied [[norepinephrine]], which acts on the liver to convert [[glycogen]] into [[glucose]] via the activation of the [[phosphorylase]] enzyme. He homogenized the liver into a membrane fraction and soluble fraction (phosphorylase is soluble), added norepinephrine to the membrane fraction, extracted its soluble products, and added them to the first soluble fraction. Phosphorylase activated, indicating that norepinephrine's target receptor was on the cell membrane, not located intracellularly. He later identified the compound as cyclic AMP ([[Cyclic adenosine monophosphate|cAMP]]) and with his discovery created the concept of second-messenger-mediated pathways. He, like Loewi, won the Nobel Prize for his groundbreaking work in endocrinology.</div>FuzzyBot