https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AEndocrinology%2F31%2FenTranslations:Endocrinology/31/en - Revision history2026-09-18T23:24:07ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Endocrinology/31/en&diff=118027&oldid=prevFuzzyBot: Importing a new version from external source2024-02-20T04:43:06Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>[[Neurohormone]]s were first identified by [[Otto Loewi]] in 1921. He incubated a frog's heart (innervated with its [[vagus nerve]] attached) in a saline bath, and left in the solution for some time. The solution was then used to bathe a non-innervated second heart. If the vagus nerve on the first heart was stimulated, negative [[inotropic]] (beat amplitude) and [[chronotropic]] (beat rate) activity were seen in both hearts. This did not occur in either heart if the vagus nerve was not stimulated. The vagus nerve was adding something to the saline solution. The effect could be blocked using [[atropine]], a known [[Enzyme inhibitor|inhibitor]] to [[heart]] vagal nerve stimulation. Clearly, something was being secreted by the [[vagus nerve]] and affecting the heart. The "vagusstuff" (as Loewi called it) causing the myotropic (muscle enhancing) effects was later identified to be [[acetylcholine]] and [[norepinephrine]]. Loewi won the Nobel Prize for his discovery.</div>FuzzyBot