https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ADiscovery_and_development_of_gliflozins%2F8%2FenTranslations:Discovery and development of gliflozins/8/en - Revision history2026-10-01T07:48:40ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Discovery_and_development_of_gliflozins/8/en&diff=114394&oldid=prevFuzzyBot: Importing a new version from external source2024-02-14T00:56:19Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>In diabetes, extracellular glucose concentration increases and this high glucose level leads to [[Downregulation and upregulation|upregulation]] of SGLT-2, leading in turn to more absorption of glucose in the kidneys. These effects cause maintenance of [[hyperglycemia]]. Because sodium is absorbed at the same time as glucose via SGLT-2, the upregulation of SGLT-2 probably leads to development or maintenance of [[hypertension]]. In study where rats were given either [[ramipril]] or [[losartan]], levels of SGLT-2 protein and [[mRNA]] were significantly reduced. In patients with diabetes, hypertension is a common problem so this may have relevance in this disease.</div>FuzzyBot