https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ADiscovery_and_development_of_gliflozins%2F23%2FenTranslations:Discovery and development of gliflozins/23/en - Revision history2026-09-08T13:18:47ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Discovery_and_development_of_gliflozins/23/en&diff=114409&oldid=prevFuzzyBot: Importing a new version from external source2024-02-14T00:56:20Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>== Structure-activity relationship (SAR) ==<br />
The [[aglycones]] of both phlorizin and dapagliflozin have weak inhibition effects on SGLT-1 and SGLT-2. Two [[Synergy#Drug synergy|synergistic]] forces are involved in binding of inhibitors to SGLTs. Different sugars on the aglycone will affect and change the orientation of it in the access vestibule because one of the forces involved in the binding is the binding of sugar to the glucose site. The other force is the binding of the aglycone, which affects the binding affinity of the entire inhibitor.</div>FuzzyBot