https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ADiscovery_and_development_of_gliflozins%2F16%2FenTranslations:Discovery and development of gliflozins/16/en - Revision history2026-05-11T13:40:32ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Discovery_and_development_of_gliflozins/16/en&diff=114402&oldid=prevFuzzyBot: Importing a new version from external source2024-02-14T00:56:20Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>== Drug development ==<br />
Phlorizin consists of glucose [[Moiety (chemistry)|moiety]] and two [[aromatic rings]] ([[aglycone]] moiety) joined by an [[alkyl]] spacer. Initially, phlorizin was isolated for treatment of fever and infectious diseases, particularly [[malaria]]. According to [[Michael Nauck]] and his partners, studies were made in the 1950s on phlorizin that showed that it could block sugar transport in the kidney, small intestine, and a few other tissues. In the early 1990s, sodium/glucose cotransporter 2 was fully characterized, so the mechanism of phlorizin became of real interest. In later studies it was said that sugar-blocking effects of phlorizin was due to inhibition of the sodium/glucose cotransporter proteins.</div>FuzzyBot