https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ADiscovery_and_development_of_angiotensin_receptor_blockers%2F41%2FenTranslations:Discovery and development of angiotensin receptor blockers/41/en - Revision history2026-07-13T20:00:59ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Discovery_and_development_of_angiotensin_receptor_blockers/41/en&diff=131498&oldid=prevFuzzyBot: Importing a new version from external source2024-03-28T01:25:31Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>All of the ARBs, except for valsartan and olmesartan, are metabolized in some way by the [[cytochrome P450]] (CYP) enzyme [[CYP2C9|2C9]], that is found in the human liver. [[CYP2C9]] is for example responsible for the metabolizing of losartan to EXP 3174 and the slow metabolizing of valsartan and candesartan to their inactive metabolites. Telmisartan is, on the other hand, in part metabolized by [[glucuronidation]] and olmesartan is excreted as the unchanged drug.<br />
Telmisartan is the only ARB that can cross the [[blood–brain barrier]] and can therefore inhibit centrally mediated effects of Ang II, contributing to even better blood pressure control.</div>FuzzyBot