https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ADiscovery_and_development_of_angiotensin_receptor_blockers%2F36%2FenTranslations:Discovery and development of angiotensin receptor blockers/36/en - Revision history2026-11-10T06:19:51ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Discovery_and_development_of_angiotensin_receptor_blockers/36/en&diff=131493&oldid=prevFuzzyBot: Importing a new version from external source2024-03-28T01:25:31Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>===Pharmacophore and structure-activity relationship===<br />
'''Pharmacophore'''<br /><br />
There are three functional groups that are the most important parts for the [[bioactivity]] of ARBs, see figure 1 for details.<br /><br />
The first one is the imidazole ring that binds to amino acids in helix 7 ([[Asparagine|Asn]]<sup>295</sup>). The second group is the biphenyl-methyl group that binds to amino acids in both helices 6 and 7 ([[Phenylalanine|Phe]]<sup>301</sup>, [[Phenylalanine|Phe]]<sup>300</sup>, [[Tryptophan|Trp]]<sup>253</sup> and [[Histidine|His]]<sup>256</sup>). The third one is the [[tetrazole]] group that interacts with amino acids in helices 4 and 5 ([[Arginine|Arg]]<sup>167</sup> and [[Lysine|Lys]]<sup>199</sup>). <br /><br />
The tetrazole group has been successfully replaced by a carboxylic acid group as is the case with telmisartan.</div>FuzzyBot