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===Binding pockets===
[[File:Bindingsite.jpg|left|thumb|300px|Fig 1. Losartan receptor binding]]
Ang II binds to AT1 receptors via various [[binding sites]]. The primary binding site is at the extracellular region of the AT1 receptor where Ang II interacts with residues in the [[N-terminus]] of the AT1 receptor and its first and third extracellular loops. The transmembrane helices also contribute to the binding via the [[C-terminal]] [[carboxyl]] group that interacts with [[Lysine|Lys]]199 in the upper part of helix 5 of the receptor; see figure 1 for details. 
The [[Salt bridge (protein and supramolecular)|ionic bridge]] formed between [[Lysine|Lys]]199 and the carboxyl terminal group of the [[Phenylalanine|Phe]]8 residue of Ang II is most likely stabilized by the [[Tryptophan|Trp]]253 residue. In addition, [[Phenylalanine|Phe]]259 and [[Aspartic acid|Asp]]263 in transmembrane helix 6 and [[Lysine|Lys]]102 and [[Serine|Ser]]105 in the outer region of transmembrane helix 3 have also been implicated in Ang II binding. This region may possibly participate in the stabilization of the receptor's ratification and in the formation of the intramembrane binding pocket.

Translations:Discovery and development of angiotensin receptor blockers/12/en - Revision history

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