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	<title>Translations:Dipeptidyl peptidase-4/2/en - Revision history</title>
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	<updated>2026-09-08T22:15:20Z</updated>
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		<title>FuzzyBot: Importing a new version from external source</title>
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		<updated>2024-03-11T13:43:40Z</updated>

		<summary type="html">&lt;p&gt;Importing a new version from external source&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;== Function ==&lt;br /&gt;
The protein encoded by the &amp;#039;&amp;#039;DPP4&amp;#039;&amp;#039; gene is an [[enzyme]] expressed on the surface of most cell types and is associated with immune regulation, [[signal transduction]], and [[apoptosis]]. It is a type II transmembrane [[glycoprotein]], but a soluble form, which lacks the intracellular and transmembrane part, is present in blood plasma and various body fluids. DPP-4 is a [[serine]] [[exopeptidase]] that cleaves X-proline or X-alanine [[dipeptide]]s from the [[N-terminus]] of [[polypeptide]]s. Peptide bonds involving the cyclic amino acid proline cannot be cleaved by the majority of proteases and an N-terminal X-proline &amp;quot;shields&amp;quot; various biopeptides. Extracellular proline-specific proteases therefore play an important role in the regulation of these biopeptides.&lt;/div&gt;</summary>
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